Molecular Formula | C18H14O3 |
Molar Mass | 278.3 |
Density | 1.32±0.1 g/cm3(Predicted) |
Melting Point | 233℃-234℃ |
Boling Point | 470.4±45.0 °C(Predicted) |
Flash Point | 210.8°C |
Vapor Presure | 5.1E-09mmHg at 25°C |
Appearance | Red powder |
Storage Condition | 2-8℃ |
Sensitive | Sensitive to light |
Refractive Index | 1.67 |
In vitro study | Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently. |
Reference Show more | 1. Ma Guichen, Duan Yifei, Zhang Hong, Jin Gaofeng, Liu Minggong, Xiong Yuqing. Study on the effect of Salvia miltiorrhiza fractions on fluvastatin metabolism based on cytochrome P450 2C9 gene polymorphism and its mechanism [J]. Chinese journal of clinical pharmacology, 2017,33(21):2171-2174. 2. [IF = 3] Qu Lala et al."Phenotypic assessment and screening of ETA/ETB receptors with label-free dynamic mass redistribution say." N-S Arch Pharmacol. 2020 Jun;393(6):937-950 3. [IF = 8.34] Song Jiao-Jiao et al."A 2-oxoglutarate-dependent dioxygenase converts dihydrofuran to furan in Salvia diterpenoids." Plant Physiol. 2021 Dec;: |